Drug Target Validation

DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c31977) has announced the addition of Strategies for Drug Target Identification and Validation See validate.
validation - The stage in the software life-cycle at the end of the development process where software is evaluated to ensure that it complies with the requirements. to their offering.

Target-based drug discovery has become the prevailing paradigm used by pharmaceutical and biotechnology companies Top 100 Biotechnology Companies
The following is a list of the top 100 biotechnology companies ranked by revenue. The first nine companies qualify for the list of the top 50 pharmaceutical companies.
..... Click the link for more information.. This approach is appealing because it holds the promise of identifying more-efficacious compounds with fewer undesirable side effects Side effects

Effects of a proposed project on other parts of the firm.
..... Click the link for more information.. Companies have therefore invested significant resources in acquiring and developing technologies for identifying and validating new drug targets. This report explores both state-of-the-art and emerging target identification and validation technologies and methods. We consider the limitations of these technologies and their impact on drug discovery, examine relevant business models, and profile selected companies with novel target identification and validation technologies.
Business Implications

--Target-based drug discovery has become the prevailing paradigm used by pharmaceutical and biotechnology companies. This approach is appealing because it holds the promise of identifying more-efficacious compounds with fewer undesirable side effects. Companies have therefore invested significant resources in acquiring and developing technologies for identifying and validating new drug targets.

--A wide array of target identification technologies is available, including genomics, gene expression profiling Microarray technology is often used for gene expression profiling. It makes use of the sequence resources created by the genome sequencing projects and other sequencing efforts to answer the question, , and proteomics pro·te·o·mics
n.
The analysis of the expression, localization, functions, and interactions of the proteins produced by the genes of an organism.
..... Click the link for more information.. Biomarkers and metabolomic profiling are emerging tools for monitoring the biological effects of manipulating a potential drug target. Technologies such as gene knockouts This article or section is in need of attention from an expert on the subject.
Please help recruit one or [ improve this article] yourself. See the talk page for details. , RNA interference RNA interference
n.
A process in which the introduction of double-stranded RNA into a cell inhibits the expression of genes.
..... Click the link for more information. (RNAi), and protein inhibition provide researchers with a multipronged mul·ti·pronged
adj.
1. Having many prongs.

2. Involving several different directions, aspects, or elements: a multipronged attack; a multipronged tax bill. approach to validating new targets. The most successful approaches combine several technologies to provide a detailed understanding of the biological effects of altering the activity of a single target.

--Target identification and validation technologies form a critical foundation for modern drug discovery. These approaches provide a rich source of intellectual property and can be valuable competitive differentiators for companies seeking proprietary positions for drugs that act through novel mechanisms. Emerging technologies such as RNAi and metabolic met·a·bol·ic
adj.
Of, relating to, or resulting from metabolism.

Metabolic
Refers to the chemical processes of an organ or organism. profiling hold a great deal of promise for improving the efficiency and efficacy of drug target validation.

Topics Covered

--Introduction

--Drug Target Identification

--Target Validation Technologies

--Impact of New Targets on Drug Discovery

--Corporate Highlights

--Outlook

Companies mentioned in this report include:

--ActivX

--Alnylam Pharmaceuticals

--Ambion

--Amphora Discovery

--Archemix

--Atugen Biotechnology

--Cenix BioScience

--Cubist Pharmaceuticals

--CuraGen

--Deltagen

--DeveloGen

--DevGen

--Dharmacon

--EpiGenesis Pharmaceuticals

--Exelixis

--GeneData

--genOway

--Icoria

--Ingenium Pharmaceuticals

--Isis Pharmaceuticals

--Lexicon Genetics

--Metabolon

--Phenomenome Discoveries

--Quark Biotech bi·o·tech
n. Informal
Biotechnology.

biotech
Noun

short for biotechnology

Noun 1.

--Rigel

--Xenogen

--Xenon Genetics

--Zygogen

For more information visit http://www.researchandmarkets.com/reports/c31977

Source: Decision Resources